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Product Usage Information

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 μg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

CD11b/ITGAM (D6X1N) Rabbit mAb recognizes endogenous levels of total CD11b/ITGAM protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human CD11b/ITGAM protein

Background

Cluster of differentiation molecule 11b (CD11b)/Integrin alpha M (ITGAM) is a transmembrane protein forming heterodimers that are composed of α and β subunits (1). CD11b is expressed by, and commonly used as a marker for, myeloid lineage cells, including neutrophils, monocytes, macrophages, and microglia (2). CD11b is phosphorylated at Ser1126 (cytoplasmic tail) in neutrophils. Research has shown that this phosphorylation event plays a role for leukocytes traveling from the blood stream to tissues (3). Furthermore, genome-wide association studies have linked CD11b to autoimmune diseases, such as systemic lupus erythematous (SLE) (4).

1. Solovjov, D.A. et al. (2005) J Biol Chem 280, 1336-45.
2. Murray, P.J. and Wynn, T.A. (2011) Nat Rev Immunol 11, 723-37.
3. Fagerholm, S.C. et al. (2006) Blood 108, 3379-86.
4. Rosetti, F. and Mayadas, T.N. (2016) Immunol Rev 269, 175-93.