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Product Usage Information

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 μg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

c-IAP2 (58C7) Rabbit mAb detects endogenous levels of total c-IAP2 protein. No cross reactivity was detected with other family members.

Species Reactivity:

Human

Species predicted to react based on 100% sequence homology:

Monkey

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val117 of human c-IAP2.

Background

The inhibitor of apoptosis protein (IAP) family consists of an evolutionarily conserved group of apoptosis inhibitors containing a conserved 70 amino acid BIR (baculovirus inhibitor repeat) domain (1,2). Human members of this family include c-IAP1, c-IAP2, XIAP, survivin, livin, and NAIP. Overexpression of IAP family members, particularly survivin and livin, in cancer cell lines and primary tumors suggests an important role for these proteins in cancer progression (3-5). In general, the IAP proteins function through direct interactions to inhibit the activity of several caspases, including caspase-3, caspase-7, and caspase-9 (5,6). In addition, binding of IAP family members to the mitochondrial protein Smac blocks their interaction with caspase-9, thereby allowing the processing and activation of the caspase (2).

1. Deveraux, Q.L. and Reed, J.C. (1999) Genes Dev 13, 239-52.
2. Deveraux, Q. L. et al. (1998) EMBO J. 17, 2215-2223.
3. Altieri, D.C. et al. (1999) Lab Invest 79, 1327-33.
4. Tamm, I. et al. (2000) Clin Cancer Res 6, 1796-803.
5. Kasof, G.M. and Gomes, B.C. (2001) J Biol Chem 276, 3238-46.
6. Deveraux, Q.L. et al. (1997) Nature 388, 300-4.