欧美gv在线观看,黑人97人人模人人爽人人喊,各类老熟女老熟妇视频在线观看 ,真人做爰高潮视频免费

Product Usage Information

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 μg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

EphB2 (D2X2I) Rabbit mAb recognizes endogenous levels of total EphB2 protein.

Species Reactivity:

Human, Mouse, Rat

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala573 of human EphB2 protein.

Background

The ephrin receptor B2 (EphB2) is an ephrin family receptor tyrosine kinase that plays an important role in regulating growth and development of multiple tissues and organs (1,2). The EphB2 transmembrane receptor protein contains a kinase domain, a PDZ motif, and a SAM domain within a conserved cytoplasmic domain. A ligand binding domain, a cysteine-rich domain, and fibronectin type III repeats comprise the conserved EphB2 extracellular domain (3). EphB2 binds with high affinity to ephrin B ligands, and to some ephrin A proteins, to initiate bidirectional signaling between neighboring cells (1,2). Upon binding, EphB2-Ephrin B2 dimers form a heterotetramer and position the receptor-ligand complex on the cell membrane to facilitate bidirectional signal transduction (3). In addition to associating with ephrin ligands, EphB2 also regulates a number of biological processes through interaction with focal adhesion kinase (FAK), NMDA receptor (NMDAR), the Rac1 guanine nucleotide exchange factor Tiam1, and p21-activated kinase (PAK1) (4-7). While some studies support a role for EphB2 as a pro-oncogenic kinase, other research suggests that EphB2 acts as a tumor suppressor (1,2,4,8).

1. Pasquale, E.B. (2008) Cell 133, 38-52.
2. Klein, R. (2009) Nat Neurosci 12, 15-20.
3. Himanen, J.P. et al. (2001) Nature 414, 933-8.
4. Wang, S.D. et al. (2012) Oncogene 31, 5132-43.
5. Nolt, M.J. et al. (2011) J Neurosci 31, 5353-64.
6. Tolias, K.F. et al. (2007) Proc Natl Acad Sci U S A 104, 7265-70.
7. Srivastava, N. et al. (2013) Mol Cell Neurosci 52, 106-16.
8. Blume-Jensen, P. and Hunter, T. (2001) Nature 411, 355-65.