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Product Usage Information

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 μg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

CD2AP Antibody detects endogenous levels of total CD2AP protein.

Species Reactivity:

Human, Mouse, Rat, Monkey

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to amino acids near the carboxy terminus of human CD2AP. Antibodies are purified by protein A and peptide affinity chromatography.

Background

CD2AP is a scaffolding protein that is thought to link membrane proteins to the cytoskeleton (1-3). It plays a role in formation of tight junctions in specialized cell types such as the slit diaphragm in the kidney glomerulus (4). CD2AP is also involved in the immunological synapse between CD2 expressing T cells and antigen presenting cells (5). It has been shown that interaction between CD2AP and other cytoskeletal proteins may regulate the endocytosis of EGFR (3).

1. Kirsch, K.H. et al. (1999) Proc Natl Acad Sci U S A 96, 6211-6.
2. Kirsch, K.H. et al. (2001) J Biol Chem 276, 4957-63.
3. Lynch, D.K. et al. (2003) J Biol Chem 278, 21805-13.
4. Kawachi, H. et al. (2006) Nephrology (Carlton) 11, 274-81.
5. Hutchings, N.J. et al. (2003) J Biol Chem 278, 22396-403.