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Product Usage Information

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 μg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

c-Abl Antibody detects endogenous levels of Abl proteins.

Species Reactivity:

Human, Mouse, Rat

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro580 of human c-Abl. Antibodies are purified by protein A and peptide affinity chromatography.

Background

The c-Abl proto-oncogene encodes a nonreceptor protein tyrosine kinase that is ubiquitously expressed and highly conserved in metazoan evolution. c-Abl protein is distributed in both the nucleus and the cytoplasm of cells. It is implicated in regulating cell proliferation, differentiation, apoptosis, cell adhesion, and stress responses (1-3). c-Abl kinase activity is increased in vivo by diverse physiological stimuli including integrin activation; PDGF stimulation; and binding to c-Jun, Nck, and RFX1 (2,4). The in vivo mechanism for regulation of c-Abl kinase activity is not completely understood. Tyr245 is located in the linker region between the SH2 and catalytic domains. This positioning is conserved among Abl family members. Phosphorylation at Tyr245 is involved in the activation of c-Abl kinase (5). In addition, phosphorylation at Tyr412, which is located in the kinase activation loop of c-Abl, is required for kinase activity (6).

1. Wang, J.Y. (2000) Oncogene 19, 5643-50.
2. Van Etten, R.A. (1999) Trends Cell Biol 9, 179-86.
3. Danial, N.N. and Rothman, P. (2000) Oncogene 19, 2523-31.
4. Shaul, Y. (2000) Cell Death Differ 7, 10-6.
5. Brasher, B.B. and Van Etten, R.A. (2000) J Biol Chem 275, 35631-7.
6. Pluk, H. et al. (2002) Cell 108, 247-259.